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NextGen USMLE Step 1 — Complete UWorld Mastery Program

Master every concept tested on the USMLE Step 1 with the NextGen USMLE UWorld Mastery Program a complete, structured video library covering all 3,600+ UWorld MCQs. Each question is explained in depth by U.S.-based residents and physicians, focusing on high-yield reasoning, first principles, and clinical correlations.Through this course, you’ll learn how to approach each question strategically, eliminate confusion, and strengthen your integration of Pathology, Pharmacology, Physiology, and Biochemistry all directly aligned with UWorld, First Aid, and Pathoma.Key Highlights:Full coverage of entire UWorld Step 1 QBank (all systems and subjects) Taught by U.S. medical residents and mentors Integrated explanations with First Aid and Pathoma references Access to recorded, high-yield discussions anytimePerfect for both independent review and guided 120-Day Marathon studentsOutcome: By the end of this program, you will have a complete command over the UWorld question bank — ready to tackle NBMEs and the Step 1 exam with confidence.

Course Content

Cardiology

Chapter 1

Master cardiac physiology — preload/afterload, pressure–volume loops, murmurs. Integrate with ECG interpretation, valvular lesions, and pharmacology (beta-blockers, ACE inhibitors, anti-arrhythmics). Emphasize pathophysiology links with hypertension and heart failure.

Lecture 1

41 minutes

Lecture 2

1 hour 40 minutes

Lecture 3

1 hour

Lecture 4

1 hour 54 minutes

Lecture 5

34 minutes

Lecture 6

2 hours 4 minutes

Lecture 7

2 hours 32 minutes

Lecture 8

2 hours 22 minutes

Lecture 9

1 hour 55 minutes

Lecture 10

2 hours 18 minutes

Lecture 11

1 hour 57 minutes

Lecture 12

2 hours 51 minutes

Lecture 13

2 hours 8 minutes

Endocrinology

Chapter 2

Focus on hormone feedback loops and endocrine pathology (thyroid, adrenal, pituitary). Link pharmacology (insulin, steroids, antithyroid meds) with mechanisms of action. Practice clinical correlations — DKA vs HHS, Cushing vs Addison.

Lecture 1

1 hour 51 minutes

Lecture 2

2 hours 46 minutes

Lecture 3

2 hours 32 minutes

Lecture 4

2 hours 32 minutes

Lecture 5

1 hour 36 minutes

Renal

Chapter 3

Understand nephron physiology and acid-base regulation. Review nephritic vs nephrotic syndromes, diuretic mechanisms, and electrolyte imbalances. Tie into hypertension management and chronic kidney disease.

LECTURE 1

1 hour 47 minutes

LECTURE 2

2 hours 48 minutes

LECTURE 3

2 hours 31 minutes

LECTURE 4

2 hours 46 minutes

LECTURE 5

2 hours 55 minutes

LECTURE 6

1 hour 29 minutes

LECTURE 7

1 hour 18 minutes

Pulmonology

Chapter 4

Cover lung volumes, gas exchange, and oxygen dissociation curve. Distinguish obstructive vs restrictive patterns and related diseases (COPD, asthma, fibrosis). Integrate pharmacology of bronchodilators and corticosteroids.

Lecture 1

2 hours 50 minutes

Lecture 2

2 hours 45 minutes

Lecture 3

2 hours 52 minutes

Lecture 4

1 hour 42 minutes

Immunology

Chapter 5

Review innate vs adaptive immunity, hypersensitivity types, and complement pathways. Master cytokines and immune cell markers (CDs). Relate immunodeficiencies and autoimmune disorders to real-world examples.

LECTURE 1

1 hour 34 minutes

LECTURE 2

2 hours

Hematology

Chapter 6

RBC disorders (anemias, hemoglobinopathies) and WBC malignancies (leukemias, lymphomas). Review coagulation cascades, platelet disorders, and transfusion medicine. Integrate with oncology pharmacology (chemotherapy side effects).

LECTURE 1

1 hour 12 minutes

LECTURE 2

1 hour 37 minutes

LECTURE 3

1 hour 42 minutes

LECTURE 4

1 hour 57 minutes

LECTURE 5

1 hour 21 minutes

Musculoskeletal (MSK)

Chapter 7

Muscles, bones, and connective tissue — key for anatomy and pathology. Focus on rheumatologic conditions (RA, SLE, gout) and related pharmacology. Remember fracture healing and bone remodeling pathways.

Lecture 1

1 hour 54 minutes

Lecture 2

1 hour 20 minutes

Lecture 3

1 hour 32 minutes

Lecture 4

1 hour 45 minutes

Lecture 5

1 hour 1 minute

Neurology

Chapter 8

Master neuroanatomy localization and neurotransmitter pathways. Learn CNS pharmacology (antiepileptics, antidepressants, antipsychotics). Review demyelinating diseases, strokes, and neurodegenerative disorders.

Lecture 1

1 hour 28 minutes

Lecture 2

2 hours

Lecture 3

2 hours 3 minutes

Lecture 4

1 hour 33 minutes

Lecture 5

1 hour 42 minutes

Lecture 6

14 minutes

Lecture 7

2 hours 13 minutes

Lecture 8

1 hour 32 minutes

Lecture 9

59 minutes

Lecture 10

2 hours 29 minutes

Gastrointestinal (GIT)

Chapter 9

Digestive physiology, absorption, and hepatobiliary system. Pathology: peptic ulcer, IBD, liver disease, gallstones, pancreatic disorders. Pharmacology: PPIs, H2 blockers, laxatives, antiemetics.

Lecture 1

1 hour 59 minutes

Lecture 2

1 hour 52 minutes

Lecture 3

1 hour 34 minutes

Lecture 4

1 hour 22 minutes

Lecture 5

1 hour 45 minutes

Lecture 6

1 hour 10 minutes

Lecture 07

1 hour 44 minutes

Lecture 08

1 hour 47 minutes

Lecture 9

1 hour

Reproductive

Chapter 10

Embryology, hormones of the menstrual cycle, and pregnancy physiology. Pathologies: PCOS, endometriosis, infertility, gynecologic cancers. Include male reproductive pharmacology (androgens, anti-androgens).

REPRODUCTIVE MALE

1 hour 23 minutes

REPRODUCTIVE FEMALE 1

1 hour 48 minutes

PHARMA REPRODUCTIVE

46 minutes

REPRODUCTIVE FEMALE 2

2 hours

REPRODUCTIVE FEMALE 3

1 hour 40 minutes

REPRODUCTIVE FEMALE 4

1 hour 18 minutes

Psychiatry

Chapter 11

Review DSM-5 major disorders and drug classes. Understand mechanism of antidepressants, antipsychotics, anxiolytics. Include behavioral science and doctor-patient ethics.

LECTURE 1

1 hour 56 minutes

LECTURE 2

1 hour 54 minutes

LECTURE 3

1 hour 29 minutes

LECTURE 4

1 hour 50 minutes

LECTURE 5

1 hour 4 minutes

Biostatistics

Chapter 12

Core formulas: sensitivity, specificity, PPV, NPV, likelihood ratios. Understand bias types, study designs, and interpreting p-values & confidence intervals. Use question practice to strengthen application.

LECTURE 1

2 hours 15 minutes

LECTURE 2

1 hour 47 minutes

LECTURE 3

2 hours 18 minutes

LECTURE 4

55 minutes

Biochemistry

Chapter 13

Pathways: glycolysis, TCA, oxidative phosphorylation, urea cycle. Master enzyme deficiencies and vitamin cofactor roles. Integrate with molecular biology (DNA replication, transcription, translation).

LECTURE 1

2 hours 1 minute

LECTURE 2

1 hour 40 minutes

LECTURE 3

1 hour 15 minutes

Pathology

Chapter 14

A complete system-based review of all pathology concepts covered in UWorld. This section focuses on disease mechanisms, key histopathological findings, and high-yield diagnostic clues tested on the USMLE. Each topic integrates pathophysiology with clinical correlations, helping students master disease patterns and identify the most tested features from UWorld question explanations.

LECTURE 1

1 hour 23 minutes

Genetics

Chapter 15

Comprehensive review of high-yield medical genetics — covering inheritance patterns, chromosomal disorders, mutations, gene mapping, and molecular techniques frequently tested on Step 1 and Step 2. Includes detailed explanations with clinical correlations and UWorld-based question discussions.

Lecture 1

1 hour 28 minutes

Lecture 2

1 hour 30 minutes

Pharmacology

Chapter 16

Systematic and easy-to-grasp coverage of pharmacokinetics, pharmacodynamics, drug mechanisms, side effects, and contraindications. Each class of drug is broken down with UWorld-style reasoning and key mnemonics for rapid recall during exams.

Lecture 1

1 hour 34 minutes

Ethics

Chapter 17

Step-oriented lectures covering bioethics principles, patient confidentiality, consent, end-of-life care, and cultural sensitivity. Includes common UWorld-type ethical scenarios to strengthen your decision-making for exam vignettes.

Lecture 1

1 hour 48 minutes

Lecture 2

1 hour 20 minutes

Lecture 3

43 minutes

NextGen USMLE Step 1 — Complete UWorld Mastery Program

EXPLORE PLANS

17 Chapters

85 Videos

149.4 hrs of video content

USMLE Step 1 – UWorld

4.7 / 5 Ratings

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